Sponsor: National Cancer Institute
Sponsor Study ID: R01 CA276066
Study Title: The Impact of Cannabis and Tobacco/Nicotine Product Co Use in Young Adults: Prospective Cessation Evaluation and Substitution
CTO #: 103964
NCT Number: NCT06239350
Phase: N/A
Protocol Type: Health Services Research
Age Group: Adults
Disease Sites:
Study Objectives: Aim 1: Substitutability and Nicotine Treatment Outcomes. Evaluate the impact of behavioral economically derived measures of substance substitutability on Week 12 end of treatment (EOT) nicotine abstinence. Hypothesis 1: Participants with greater substitutability patterns will have lower rates of 7-day point prevalence abstinence from nicotine at EOT compared to patterns indicating a complementary relationship. Aim 2: Cannabis Demand and Use During Nicotine Treatment. Determine if treatment-induced nicotine abstinence, reduction or withdrawal is (a) associated with co-occurring changes in cannabis demand and use and (b) if substitutability modifies this relationship. Hypothesis 2: Nicotine use/withdrawal and associated changes in cannabis use and demand will be moderated by time varying changes in substitutability. Aim 3: Nicotine and Cannabis Use Changes During Treatment. Assess the reciprocal prospective relationship between nicotine and cannabis use (including reduction and abstinence) during nicotine treatment. Hypothesis 3: Cross-lagged changes in nicotine and cannabis use during treatment will have a positive correlation; i.e., increased cannabis use in the prior week will be associated with increased current nicotine use.