Sponsor: COG
Sponsor Study ID: ACNS1723
Study Title: A Phase 2 Study of Dabrafenib (NSC# 763760) With Trametinib (NSC# 763093) After Local Irradiation in Newly Diagnosed BRAF V600 Mutant High Grade Glioma (HGG)
CTO #: 103218
NCT Number: NCT03919071
Phase: II
Protocol Type: Treatment
Age Group: Children
Disease Sites: Brain and Nervous System
Study Objectives: This phase II trial studies how well the combination of dabrafenib and trametinib works after radiation therapy in children and young adults with high grade glioma who have a genetic change called BRAF V600 mutation. Radiation therapy uses high energy rays to kill tumor cells and reduce the size of tumors. Dabrafenib and trametinib may stop the growth of tumor cells by blocking BRAF and MEK, respectively, which are enzymes that tumor cells need for their growth. Giving dabrafenib with trametinib after radiation therapy may work better than treatments used in the past in patients with newly-diagnosed BRAF V600-mutant high-grade glioma.