Below are the NCI Cooperative Group active protocol list within the HCC Clinical Trials Network program. If you wish to access the cooperative group protocol documents and updates, please use the cooperative group links below. Protocol documents are available to cooperative group members who have an active username and password. If you are having difficulty accessing a protocol document, contact your research coordinator or the Network office.

last updated April 27, 2010

Disease Site	Coop Protocol Number	Protocol Title	CTN Member
Breast	NSABP B-39/ RTOG 0413	A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) vs. Partial Breast Irradiation (PBI) for Women with Stage 0, I, or II Breast Cancer	Georgetown Hospital System PI: Eric Aguero, MD   Carolina Regional Cancer Center PI: Todd Williams, MD
Gastrointestinal	CALGB C80405	A Phase II Trial of Irinotecan, 5FU, Leucovorin or Oxaliplatin, 5FU, Leucovorin with Bevacizumab or Cetuximab (C225), or with the Combination of Bevacizumab and Cetuximab for Patients with Untreated Metastatic Adenocarcinoma of the Color or Rectum	Georgetown Hospital System PI: Darren Mullins, MD
Gastrointestinal	ECOG 5202	A Randomized Phase III Study Comparing 5-FU, Leucovorin, and Oxaliplatin Vs. 5-FU, Leucovorin, Oxaliplatin, and Bevacizumab in Patients with Stage II Colon Cancer at High Risk to Determine Prospectively to Prognostic value of Molecular Markers	Georgetown Hospital System PI: Darren Mullins, MD
Breast	ACOSOG Z1031	A Randomized Phase III Trial Comparing 16 to 18 weeks of Neoadjuvant Exemestane (25 mg daily), Letrozole (2.5 mg) or Anastrozole (1 mg) in Postmenopausal Women with Clinical Stage II and III Estrogen Receptor Positive Breast Cancer	Hilton Head Regional Medical Center PI: Virginia Herrmann, MD
Genitourinary	RTOG 0534	A Phase III Trial of Short Term Androgen Deprivation with Pelvic Lymph Node or Prostate Bed Only Radiotherapy (SPORT) in Prostate Cancer Patients with a Rising PSA After Radical Prostatectomy	Carolina Regional Cancer Center PI: Todd Williams, MD
Thoracic	CALGB 30610/ RTOG 0538	Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer Also Receiving Cisplatin and Etoposide	Georgetown Hospital System PI: Eric Aguero, MD
Breast	ACOSOG Z1071	A Phase II Study Evaluating the Role of Sentinel Lymph Node Surgery and Axillary Lymph Node Dissection Following Preoperative Chemotherapy in Women with Node Positive Breast Cancer (T1-4, N1-2, M0) at Initial Diagnosis	Hilton Head Regional Medical Center PI: Virginia Herrmann, MD   Lexington Medical Center PI: Lynn Tucker, MD